Pulsed Radiofrequency of S2-4 Versus Ganglion Impar Neurolysis for Severe Perianal and Perineal Pain in Cancer Patients

National Cancer Institute, Egypt

Status: Completed

Conditions: Analgesia

Treatments: Procedure: Ganglion Impar Neurolysis; Procedure: Bilateral S2, S3 and S4 Pulsed radiofrequency

Study type: Interventional

Funder types: Other

Identifiers

NCT05591430

AP2207-50108

Details and patient eligibility

About

Perineal pain resulting from malignancy is usually severe. Pain can be related to the malignancy or as a complication related to the treatment. several modalities are adopted to control such pain starting from medical management to interventional pain procedures.

Full description

Perineal pain resulting from malignancy is usually severe. Pain can be related to the malignancy or as a complication related to the treatment. several modalities are adopted to control such pain starting from medical management to interventional pain procedures. Ganglion impar block has been traditionally used for treatment of such perineal pain. Radiofrequency of sacral dorsal root ganglia can be used as an alternative for pain control.

Enrollment: 40 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients aged 18-75 years
• ASA II-III with perianal and perineal pain related to cancer

Exclusion criteria

• patient refusal
• coagulation defects
• abnormal kidney or liver functions
• local infection at site of injection

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Ganglion Impar Neurolysis

Active Comparator group

Description:

Block of ganglion impar using neurolytic

Treatment:

Procedure: Ganglion Impar Neurolysis

Bilateral S2, S3 and S4 Pulsed radiofrequency

Experimental group

Description:

Pulsed radiofrequency of S2-S4

Treatment:

Procedure: Bilateral S2, S3 and S4 Pulsed radiofrequency