Pulsed Radiofrequency Versus Hyaluronidase Hydrodissection for Treatment of Carpal Tunnel Syndrome

Sohag University

Status: Not yet enrolling

Conditions: Carpal Tunnel Syndrome (CTS)

Treatments: Procedure: Pulsed Radiofrequency; Procedure: Hyaluronidase Hydrodissection

Study type: Interventional

Funder types: Other

Identifiers

NCT07269613

Soh-Med-25-9-20MS

Details and patient eligibility

About

The aim of this study is to compare the clinical efficacy and safety of ultrasound-guided pulsed radiofrequency and hyaluronidase hydrodissection in the treatment of carpal tunnel syndrome. This research seeks to evaluate both techniques in terms of pain relief, functional improvement, nerve conduction parameters, and potential complications, in order to identify the more effective minimally invasive approach for managing carpal tunnel syndrome.

Enrollment: 56 estimated patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Adults aged 20-80 years
2. Clinical diagnosis of CTS with symptoms for at least 3 months
3. Electrophysiological evidence of mild to moderate CTS
4. No previous intervention for CTS in the affected hand

Exclusion criteria

1. Previous wrist surgery or trauma
2. Medical history of polyneuropathy, thoracic outlet syndrome, or brachial plexopathy
3. Coagulopathy or local infection at injection site
4. Pregnancy or breastfeeding

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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56 participants in 2 patient groups

Group A (PRF Group)

Active Comparator group

Description:

Group A (PRF Group): will Receive ultrasound-guided pulsed radiofrequency to the median nerve at the carpal tunnel.

Treatment:

Procedure: Pulsed Radiofrequency

Group B (HD Group)

Active Comparator group

Description:

Group B (HD Group): will Receive ultrasound-guided hydrodissection of the median nerve using hyaluronidase solution.

Treatment:

Procedure: Hyaluronidase Hydrodissection