Pupillary Diameter Under Different Concentrations of Propofol

Hôpital Armand Trousseau

Status: Completed

Conditions: Anesthesia

Treatments: Drug: Propofol; Device: Pupillary diameter measurement

Study type: Interventional

Funder types: Other

Identifiers

NCT02998424

PD and propofol

Details and patient eligibility

About

Resting pupillary diameter was measured at a randomized Effect-site target concentration of propofol used as a sole anesthetic.

Enrollment: 40 patients

Sex: All

Ages: 13 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient who has reached puberty
• ASA I or II who is scheduled for elective surgery under general anesthesia

Exclusion criteria

• neurologic, metabolic, ocular disease
• chronic pain
• under medication that interferes with autonomic nervous system
• obesity
• patient requiering a rapid sequence induction

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 3 patient groups

Propofol 1 µg/ml

Experimental group

Description:

Patients received a propofol infusion at an effect-site concentration of 1 µg/ml at the beginning of induction of general anesthesia for elective surgery. Pupillary diameter measurement after 10 minutes.

Treatment:

Device: Pupillary diameter measurement

Drug: Propofol

Propofol 2 µg/ml

Experimental group

Description:

Patients received a propofol infusion at an effect-site concentration of 2 µg/ml at the beginning of induction of general anesthesia for elective surgery. Pupillary diameter measurement after 10 minutes.

Treatment:

Device: Pupillary diameter measurement

Drug: Propofol

Propofol 3 µg/ml

Experimental group

Description:

Patients received a propofol infusion at an effect-site concentration of 3 µg/ml at the beginning of induction of general anesthesia for elective surgery. Pupillary diameter measurement after 10 minutes.

Treatment:

Device: Pupillary diameter measurement

Drug: Propofol