Pupillary Dilation After Incremental Tetanic Stimulations Under Ketamine Sedation

Pr Isabelle CONSTANT

Status: Completed

Conditions: Pain; Anesthesia

Treatments: Procedure: Tetanic stimulations of incremental intensities; Drug: ketamine

Study type: Interventional

Funder types: Other

Identifiers

NCT02648412

Pupillo ketamine

Details and patient eligibility

About

The aim of the study was to describe the relationship between the intensity of a standardized tetanic stimulation and the associated reflex pupillary dilation in patients under ketamine sedation.

After an intravenous bolus of 1 mg/kg of ketamine, tetanic stimulations were performed every minute at increasing intensities of 10, 20, 30, 40 and 60 milliamps (similar to the stimulations of neuromuscular blocking agents monitoring). Pupillary diameter was measured before and after each stimulation.

Enrollment: 24 patients

Sex: All

Ages: 2 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient admitted to pediatric burns care unit
• Burnt skin area 5-40%
• Scheduled for a dressing change under ketamine sedation

Exclusion criteria

• Neurologic or ophthalmic disease

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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24 participants in 1 patient group

Ketamine sedation

Experimental group

Description:

Procedure scheduled under ketamine sedation. Baseline pupillary diameter measurement in alert subjects. Injection of a bolus of 1 mg/kg of ketamine. Every minute, tetanic stimulations of incremental intensities (10-20-30-40-60 milliamps), during 5 seconds. Pupillary diameter measurement before and after each stimulation. End of study period, beginning of procedure.

Treatment:

Procedure: Tetanic stimulations of incremental intensities

Drug: ketamine