Pupillary Dilation Reflex (PDR) Evaluation During General Anesthesia

Antwerp University Hospital (UZA)

Status

Completed

Conditions

Pain

Treatments

Device: Pupil dilation reflex measurement

Study type

Interventional

Funder types

Other

Identifiers

NCT02942316

16/40/410

Details and patient eligibility

About

In this study, the pupillary dilation reflex is measured as a nociceptive indicator during elective abdominal surgery under general anesthesia.

Full description

An infrared camera of the video pupillometer measures the pupillary dilation reflex (PDR) in response of a nociceptive stimulus. This autonomic reflex, parasympathetic mediated in sedated patients, can be generated by various pain stimuli (built in standardized protocol, surgical incision, ...) The PDR is a robust reflex, even in patients under general anesthesia, and provides a potential evaluation of the autonomous circuit within the nociceptive evaluation based on pupil dilation upon A-delta and C fibers in both electrical or mechanic stimulation. This mono-centric project involving American Society of Anesthesiologists (ASA) classification I-II patients undergoing elective abdominal surgery under general anesthesia are recruited. Enrolled patients perioperative undergo PDR measurements at four different standardized times.

Enrollment

41 patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Scheduled abdominal surgery
ASA I-II

Exclusion criteria

History of eye deformity, invasive ophthalmologic surgery, impaired pupil reflex in advance
Kown cranial nerve(s) deficit
Infection of the eye
Predicted difficult airway management (DAF Guidelines)
Chronic opioid use (>3 months)
Ongoing treatment with beta-blockers, dopamine antagonists, topical atropine