Pupillary Response After Glaucoma Medication (pupil)

Glostrup University Hospital, Copenhagen

Status: Completed

Conditions: Drug Effect (Glaucoma Drugs)

Treatments: Drug: Latanoprost; Drug: Timolol; Drug: Dorzolamide

Study type: Interventional

Funder types: Other

Identifiers

NCT02522039

GlostrupUH

Details and patient eligibility

About

Investigation of the effect on the pupillary constriction by latanoprost, dorzolamide,timolol in healthy subjects. The pupillary constriction is compared to no drug.

Enrollment: 21 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy subjects

Exclusion criteria

• ophthalmological diseases
• systemic disease
• smoking
• refractive error >= 6 diopters

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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21 participants in 4 patient groups

Latanoprost

Experimental group

Description:

solution, 1 drop of 50ug/ml latanoprost, was given to study eye after washout period of 1 week between drugs

Treatment:

Drug: Latanoprost

Timolol

Experimental group

Description:

solution, 1 drop of 5mg/ml timolol , was given to study eye after washout period of 1 week between drugs

Treatment:

Drug: Timolol

dorzolamide

Experimental group

Description:

solution, 1 drop of 20 mg/ml dorzolamide, was given to study eye after washout period of 1 week between drugs

Treatment:

Drug: Dorzolamide

Other

No Intervention group

Description:

no drug given and pupil measurements were performed before and at 30 and 180 min at equivalent hours as drugs measurements