Pupillometry Guided Remifentanil Administration and Total Opioid Consumption During Propofol - Remifentanil TCI

Pr Isabelle CONSTANT

Status: Completed

Conditions: Pain

Treatments: Other: Standard practice; Device: Videopupillometer Algiscan; Drug: Propofol; Drug: Remifentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT02576600

Anesthesie Trousseau 001

Details and patient eligibility

About

The aim of this prospective randomized study was to evaluate the impact of peroperative pupillometry monitoring on per and post-operative opioid consumption in major gynecological surgery. All patients were anesthetized with TCI of propofol and remifentanil. In the intervention group, peroperative remifentanil target was guided by pupillometry. In the other group, remifentanil was administered according to standard practice.

Enrollment: 65 patients

Sex: Female

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-II
• Elective gynecological surgery
• No ophtalmologic or neurologic disease
• No chronic analgesic medication
• Expected length of surgery 60 minutes minimum

Exclusion criteria

• ophtalmologic or neurologic disease
• chronic analgesic medication

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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65 participants in 2 patient groups

PUPILLO

Experimental group

Description:

Videopupillometer Algiscan peroperative remifentanil target concentration adapted every five minutes to pupillary diameter in patients under propofol and remifentanil TCI

Treatment:

Drug: Remifentanil

Drug: Propofol

Device: Videopupillometer Algiscan

STANDARD

Sham Comparator group

Description:

peroperative remifentanil target concentration as standard practice in patients under propofol and remifentanil TCI

Treatment:

Drug: Remifentanil

Drug: Propofol

Other: Standard practice