Pupillometry in Horner's Syndrome

University of Zurich (UZH)

Status: Unknown

Conditions: Stroke; Horner's Syndrome; Dissection Carotid Artery

Treatments: Device: Automated pupillometry

Study type: Interventional

Funder types: Other

Identifiers

NCT02978079

KEK-Nr. 2016-02151

Details and patient eligibility

About

Horner's syndrome (HS) is a result of interruption of the sympathetic innervation to the eye and ocular adnexa, which can occur due to carotid artery dissection (CAD), along which the sympathetic nerve fibers travel to reach the eye. Dissection of the carotid artery is one of the etiologies for ischemic stroke in young patients.

In our current study, we will explore the diagnostic accuracy of automated binocular pupillometry in the diagnosis or HS, and its potential in identifying dissection of the carotid artery in patients of young age who suffer ischemic stroke.

Enrollment: 135 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults 60 years of age or younger
• Acute stroke (less than 72 hours from admission)
• Informed Consent as documented by signature (Appendix Informed Consent Form)
• Ability to understand the study information and consent form

Exclusion criteria

• known history of HS
• Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.
• Medications affecting pupillary response
• History of ocular surgery affecting the pupil

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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135 participants in 1 patient group

Pupillometry in stroke patients

Experimental group

Description:

All eligible patients will undergo pupillometry test for the finding of Horner's syndrome

Treatment:

Device: Automated pupillometry