QLB After Nephrectomy

Medical University of Lublin

Status: Completed

Conditions: Chronic Postoperative Pain; Pain, Postoperative

Treatments: Device: PCA; Drug: Sevoflurane; Drug: Oxycodone; Drug: Fentanyl; Drug: Rocuronium; Procedure: QLB; Procedure: GA

Study type: Interventional

Funder types: Other

Identifiers

NCT03529201

KE-0254/328/2017

Details and patient eligibility

About

Oxycodone consumption and postoperative pain intensity in patients undergoing nephrectomy procedures. Of all study participants, 50% will obtain quadratus lumborum block (QLB).

Full description

Patients undergoing nephrectomy procedures will be allocated to one of the study arms. At the end of an operation, still under general anesthesia, 50% patients will obtain QLB with ropivacaine.

Ultrasound-guided QLB will be performed on the side of surgery with 0.375% ropivacaine solution (0.2 mL per kg).

Every patient will get patient-controlled analgesia pump with oxycodone in the postoperative period.

Postoperative pain will be measured with VAS (visual-analogue scale) 2, 4, 8, 12 and 24 hours after the end of the operation. 24 -hours period.

At the 1, 3, 6 months patients will be interviewed by phone to assess neuropathic pain. Neuropathic Pain Symptom Inventory (NPSI) will be used.

Enrollment: 105 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• obtained consent
• nephrectomy procedure

Exclusion criteria

• coagulopathy allergy to local anesthetics depression, antidepressant drugs treatment epilepsy usage of painkiller before surgery addiction to alcohol or recreational drugs

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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105 participants in 2 patient groups

QLB

Experimental group

Description:

At the end of surgery, QLB with ropivacaine will be done on the side of the operation.

Treatment:

Procedure: GA

Procedure: QLB

Drug: Rocuronium

Drug: Fentanyl

Drug: Oxycodone

Drug: Sevoflurane

Device: PCA

Control

Experimental group

Description:

Standard care. No regional blocks.

Treatment:

Procedure: GA

Drug: Rocuronium

Drug: Fentanyl

Drug: Oxycodone

Drug: Sevoflurane

Device: PCA