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QLESP Block Versus Periarticular Infiltration for Postoperative Analgesia in Hip Surgery

H

Huazhong University of Science and Technology

Status

Enrolling

Conditions

Regional Anaesthesia

Treatments

Drug: ropivacaine

Study type

Interventional

Funder types

Other

Identifiers

NCT06688136
WHUH20241101

Details and patient eligibility

About

Local and/or regional analgesia techniques are critical components of an optimal multimodal analgesia technique, as they have been shown to improve pain relief as well as reduce opioid requirements. Optimal pain management technique balances pain relief with concerns about safety and adverse effects associated with analgesic techniques. Periarticular infiltration (PAI) is increasingly included as a component of multimodal analgesia technique for patients undergoing THA, as it provides improved postoperative pain relief with no effects on quadriceps function. Recently, our group has developed a novel transmuscular quadratus lumborum and modified erector spinae plane (QLESP) block, which is characterized by simple operation, high efficiency, and wide dermatomal coverage of sensory block. Therefore, we designed a randomized controlled trial to compare ultrasound-guided QLESP with PAI as a component of non-opioid analgesic regimen in patients undergoing THA via posterior approach. We hypothesized that QLESP would provide superior analgesia when compared with PAI. The primary outcome of the study was postoperative opioid requirements within the initial 24-h postoperative period after THA. The secondary objectives were to compare pain scores, postoperative quadriceps strength, the time to first rescue analgesia, opioid-related adverse effects, time to ambulation, and the time to hospital discharge.

Enrollment

80 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. Age 18-65 yrs
  2. American Society of Anesthesiologists classification 1-3
  3. Body mass index between 20 and 35 (kg/m2)
  4. Undergo elective primary unilateral THA via a posterolateral approach
  5. Informed consent

Exclusion criteria

  1. A known allergy to the drugs being used
  2. Pre-existing neuropsychiatric disorders or language barrier
  3. Analgesics intake, history of substance abuse
  4. Contraindications to peripheral nerve block
  5. Acute cerebrovascular disease
  6. Severe liver failure

Trial design

Primary purpose

Other

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

80 participants in 2 patient groups

transmuscular quadratus lumborum and modified erector spinae plane (QLESP) block
Experimental group
Description:
Twenty ml of 0.4% ropivacaine was administered between the erector spinae muscle and the transverse process. Twenty ml of 0.4% ropivacaine was subsequently given between the quadratus lumborum and the psoas major muscles.
Treatment:
Drug: ropivacaine
Infiltration
Active Comparator group
Description:
Periarticular infiltration of 40 ml of 0.4% ropivacaine prior to closing the incision
Treatment:
Drug: ropivacaine

Trial contacts and locations

1

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Central trial contact

Xi Wu

Data sourced from clinicaltrials.gov

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