QST, Blink Reflex and Nociceptive Flexion Reflex in Headache

University of Liege

Status: Unknown

Conditions: Head Pain

Study type: Observational

Funder types: Other

Identifiers

NCT04585698

ULiege_CHEPS_AM_MM_JS

Details and patient eligibility

About

The aim of this study is to compare central and peripheric sensitization in headache patients at Baseline (T0) and 1 month after (T1) a treatment with an anti-CGRP (Fremanezumab-Ajovy).

Full description

20 patients and 20 healthy subjects will be enrolled. The headache patients will be recruited just before starting their treatment and 1 month after (corresponding to the efficacy peak). Hot and cold stimulations will be delivered with the ATS probe from the Medoc Pathway on the forehead and on the hand (palmar face) to determine painful threshold to warm/cold stimuli. A blink reflex will be generated with a concentric electrode placed over the eyebrow and with active/earth electrodes linked to the EMG machine for the recording. For the nociceptive flexion reflex, a cutaneous stimulation will be applied on the arm and the response recorded on the corresponding muscles.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: patients with headache which are about to receive a treatment with fremanezumab

Exclusion Criteria:

• medication changes 1 month prior to the test
• neuropathy
• acute or chronic pain
• medications having effects on the central nervous system
• other disease

Trial design

40 participants in 2 patient groups

headache patients

healthy subjects