QST-Pupillometry in Sickle Cell Disease Patients

Julia Finkel

Status

Completed

Conditions

SCD With Severe Phenotype (HbSS, HbSβ0 Thalassemia, HbSOARab)

Treatments

Other: Quantitative sensory testing

Study type

Observational

Funder types

Other

Identifiers

NCT02242058

QST-Pupillo3614

Details and patient eligibility

About

There has been little progress for effective treatment of pain in sickle cell disease (SCD) patients. Many organizations have recognized that understanding the causes and reducing the burden of pain in SCD is critical in order to improve the quality of life in SCD patients. As patients with SCD face the challenge of living with both acute and chronic pain which is often improperly treated, our translational and interdisciplinary project aims to identify objective measures of pain sensitivity and its biochemical and genetic correlates. We hypothesize that SCD patients will have decreased tolerance to thermal and electrical stimuli.

Enrollment

96 patients

Sex

All

Ages

13 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

SCD with severe phenotype (HbSS, HbSbeta0 thalassemia, HbSOArab)
Relatives of SCD patients who do not have sickle cell trait or SCD; healthy controls

Exclusion criteria

Completed overt clinical stroke or transient ischemic attack;
Known severe vasculopathy or Moyamoya disease on brain MRA (Magnetic Resonance Angiography).
history of having consumed alcohol within the last 12 hours prior to testing.

Trial design

96 participants in 5 patient groups

High frequency pain group

Description:

39 pediatric or adult patients with high pain frequency (greater than or equal to 3 ER visits and/or hospitalizations for pain per year over the last two years)

Treatment:

Other: Quantitative sensory testing

Low Pain Frequency group

Description:

39 pediatric or adult patients with low pain frequency (less than or equal to 1 severe pain episode for the last two years)

Treatment:

Other: Quantitative sensory testing

Healthy control group

Description:

39 pediatric or adult relatives of sickle cell disease patients, who do not have the sickle cell trait of SCD.

Treatment:

Other: Quantitative sensory testing