QT Variability Pre and Post Cardioversion (DCCV)

Vanderbilt University

Status: Completed

Conditions: Atrial Fibrillation

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00885391

060908

R01HL085690-01A2 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study is to learn whether the chemicals in the blood and urine are different when the heart is atrial fibrillation compared to normal sinus rhythm.

Full description

Atrial Fibrillation variably activates the renin-angiotensin-aldosterone system (RAAS), stimulates the sympathetic nervous system, generates oxidant stress, produces natriuretic peptides, and increases ventricular rate. These are interrelated responses and the extent to which these or other pathophysiologic responses determine QT interval during and after Atrial Fibrillation (AF) is unknown. In this study, the QT variability is related to those potential markers in patients with AF undergoing elective DC-cardioversion.

Enrollment: 219 patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• At least 21 years of age
• Scheduled to undergo an elective DC-Cardioversion of atrial fibrillation or atrial flutter at Vanderbilt University Medical Center

Exclusion criteria

• Undergoing emergent DC-Cardioversion of atrial fibrillation for hemodynamic instability
• Undergoing DC-Cardioversion for post-cardiac surgery
• Dual chamber pacemakers