Quad Resection (Hot Snare vs Cold Snare vs Hot EMR vs Cold EMR)

Indiana University

Status: Completed

Conditions: Colon Cancer; Colon Adenoma; Colon Polyp

Treatments: Procedure: Cold Snare; Procedure: Cold EMR; Procedure: Hot EMR; Procedure: Hot Snare

Study type: Interventional

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT03462706

1711062130

Details and patient eligibility

About

The study will compare the use of cold snare, hot snare, cold EMR, and hot EMR for polyp resection. Although previous studies have compared two of the potential resection methods, no previous study has evaluated all four of the resection methods.

Full description

The optimal method for removal of polyps 6-9 and 10-15 mm in size is not established. In this study, we propose to evaluate four different treatments for polyps (sized 6mm-15mm). The four treatments are cold snaring without injection, hot snaring without injection, cold EMR, and hot EMR. This study aims to help to establish the optimal resection technique for 6-9 and 10-15 mm polyps.

Enrollment: 238 patients

Sex: All

Ages: 40+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged 40 years or older
• Ability to provide informed consent

Exclusion criteria

• Subjects with a history of Inflammatory Bowel Disease
• Lesions less than 6mm or greater than 15mm in largest dimension

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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238 participants in 4 patient groups

Cold Snare

Experimental group

Description:

Polyps sized 6mm to 15mm found during colonoscopy will be removed using cold snare techniques.

Treatment:

Procedure: Cold Snare

Hot Snare

Experimental group

Description:

Polyps sized 6mm to 15mm found during colonoscopy will be removed using hot snare techniques.

Treatment:

Procedure: Hot Snare

Cold EMR

Experimental group

Description:

Polyps sized 6mm to 15mm found during colonoscopy will be removed using cold EMR techniques.

Treatment:

Procedure: Cold EMR

Hot EMR

Experimental group

Description:

Polyps sized 6mm to 15mm found during colonoscopy will be removed using hot EMR techniques.

Treatment:

Procedure: Hot EMR