Quadratus Lumborum Block After Living Donor Kidney Transplantation

Seoul National University

Status: Completed

Conditions: Analgesia

Treatments: Procedure: Transmuscular quadratus lumborum block; Procedure: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT04908761

2104-083-1211

Details and patient eligibility

About

The aim of this study is to evaluate the postoperative analgesic effect of quadratus lumborum block in patient undergoing a living donor kidney transplant under general anesthesia.

Full description

The purpose of this study was to investigate whether postoperative pain is significantly reduced when TQL block was additionally performed after surgery in patients undergoing living-donor kidney transplantation. Therefore, investigator hypothesized that the analgesic consumption for postoperative 24 hours will decrease in TQL group compared to the control group. For secondary outcomes, the pain score at rest/ movement up to 48 hours after surgery, the time until the first pain reliever is requested, whether and how often rescue analgesics are administered for 48 hours, the incidence and severity of nausea and vomiting during the 48 hours after surgery, patient's satisfaction with post-pain control and the number of hospital stays were investigated. Overall, the aim of this study is to evaluate the postoperative analgesic effect of quadratus lumborum block in patients undergoing a living donor kidney transplantation under general anesthesia.

Enrollment: 88 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients over 19 years of age undergoing elective living donor kidney transplantation under general anesthesia in Seoul National University Hospital

Exclusion criteria

• Patients with severe pain before surgery

  • Patients with a history hypersensitivity reactions on fentanyl or ropivacaine

    • Patients who cannot maintain patient-controlled analgesia (PCA) by themselves

      ④ Patients with skin diseases or infections in the area where quadratus lumborum block is applied

      ⑤ Any other cases that researchers determine that it is inappropriate for this clinical trial

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

88 participants in 2 patient groups, including a placebo group

Transmuscular quadratus lumborum block group

Experimental group

Description:

Patients assigned to the Transmuscular Quadratus Lumborum (TQL) block group receive the Transmuscular Quadratus Lumborum block in a lateral decubitus position with the surgical site facing up before recovery of general anesthesia after surgery. For the block, 30cc of 0.375% ropivacaine is used.

Treatment:

Procedure: Transmuscular quadratus lumborum block

Control group

Placebo Comparator group

Description:

For patients assigned to the control group, 30cc of 0.9% normal saline is used for Transmuscular Quadratus Lumborum block.

Treatment:

Procedure: Placebo