Quadratus Lumborum Block : Local Anesthesia Versus Placebo

Kyungpook National University

Status: Completed

Conditions: Colorectal Disorders; Loop Ileostomy

Treatments: Procedure: Quadratus lumborum block using ropivacaine; Procedure: Quadratus lumborum block with normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT03411096

KNUHC02

Details and patient eligibility

About

Opioid analgesics have many side effects. Quadratus lumborum (QL) block is one kind of regional nerve block that can reduce the side effects of opioid analgesics. The investigators hypothesize that QL block with local analgesics (ropivacaine) can significantly reduce pain intensity in comparison with placebo.

Full description

Opioid analgesics have been used to control the pain. However, many postoperative complication, such as nausea, vomiting, constipation, ileus, etc are related to opioid usage. Recently, local or regional pain nerve block, such as transversus abdominis plane block, wound infiltration, have been reported in several studies. Quadratus lumborum (QL) block was first introduced in the abstract of 2007 European Society of Regional Anesthesia. The effect is longer and more than that of transversus abdominis plane block because it works close to the spinal cord nerves. The QL block can be an effective pain control method for patients who underwent ileostomy closure. The aim of this study is to compare pain intensity after ileostomy closure between QL block (ropivacaine) group and placebo group (normal saline).

Enrollment: 57 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 20-75 years, either sex
• Patients scheduled to undergo elective ileostomy repair surgery under general anesthesia.
• Patients underwent curative surgery and ileostomy due to colorectal cancer.
• Willingness and ability to sign an informed consent document

Exclusion criteria

• Allergies to anesthetic or analgesic medications
• Contraindication to the use of locoregional anesthesia
• Chronic opioid use
• Coagulopathy, Impaired kidney function, uncontrolled diabetes, psychiatric disorders, severe cardiovascular impairment or chronic obstructive lung disease
• Necessity of major resection other than colorectal, palliative surgery
• BMI above 35kg/m2
• American Society of Anesthesiologists (ASA) physical status above 3

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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57 participants in 2 patient groups, including a placebo group

Quadratus lumborum block

Experimental group

Description:

Quadratus lumborum block with 0.75% ropivacaine

Treatment:

Procedure: Quadratus lumborum block using ropivacaine

Placebo

Placebo Comparator group

Description:

Quadratus lumborum block with normal saline

Treatment:

Procedure: Quadratus lumborum block with normal saline