Quadratus Lumborum Block Versus Epidural for Laparoscopic Nephrectomy Kidney Donor

University of Indonesia (UI)

Status: Completed

Conditions: Renal Transplant Donor of Left Kidney

Treatments: Procedure: Continuous Epidural; Procedure: Quadratus Lumborum Block

Study type: Interventional

Funder types: Other

Identifiers

NCT03520205

IndonesiaUAnes021

Details and patient eligibility

About

This study aimed to compare Quadratus Lumborum Block to Epidural on Stress Response and Perioperative Cellular Immunological Function of Laparoscopic Nephrectomy Kidney Donor

Full description

Sixty-two subjects were given informed consent before enrolling the study and randomized into two groups; quadratus lumborum block and epidural. Non-invasive blood pressure monitor, electrocardiogram (ECG), and pulse-oxymetry were set on the subjects in the operation room. General anesthesia induction was done by fentanyl 2 mcg/kg and propofol 1-2 mg/kg. Endotracheal tube (ETT) intubation was facilitated with Atracurium 0.5mg/kg as muscle relaxant. Maintenance was done by sevoflurane, oxygen, and compressed air. On quadratus lumborum block group, bilateral block using ultrasound will be performed with stimuplex 100mm needle with 20 cc of bupivacaine 0.25% as regimen. On epidural group, epidural catheter was inserted under general anaesthesia on left lateral decubitus position (5 cm depth inside the epidural space) at level Th10-Th11. The catheter insertion was confirmed with vacuum aspiration and negative test-dose. Before first incision, patient will be given continuous epidural Bupivacaine 0.25% 6 mL/hour. Blood sample was drawn for interleukin-6, blood glucose, and c-reactive protein as baseline data. After surgery, patient were extubated until fully conscious and can follow command verbally. Patient will be transported in recovery room post operation.

Enrollment: 62 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Kidney donor patients undergoing laparoscopic nephrectomy
• Body mass index below 30
• Duration of surgery 4 to 6 hours
• Patients who agreed to participate in this study and sign informed consent.

Exclusion criteria

Have contraindication for quadratus lumborum block

• Have contraindication for epidural
• Previous history of local anesthetic drug allergy
• inability to communicate

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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62 participants in 2 patient groups

Quadratus Lumborum Block

Active Comparator group

Description:

Patient will receive quadratus lumborum block

Treatment:

Procedure: Quadratus Lumborum Block

Continuous Epidural

Active Comparator group

Description:

Patient will receive epidural anesthesia

Treatment:

Procedure: Continuous Epidural