Quality of Awakening and Impact on Cognitive Function After Administration of Sugammadex in Robotic Radical Cystectomy

Regina Elena Cancer Institute

Status: Completed

Conditions: Anesthesiology Management

Treatments: Drug: Neostigmine; Drug: sugammadex

Study type: Interventional

Funder types: Other

Identifiers

NCT02454504

307.CI

Details and patient eligibility

About

With the aim of enhancing the quality of surgery, the robotic cystectomy is often conducted using continuous intravenous infusion of curare, which ensures maximum neuromuscular relaxation until the end of the intervention. Sugammadex, administered for the reversal of deep neuromuscular blocked, enable rapid awakening. Moreover, Sugammadex seems to have a positive effect also on the recovery of cognitive function, psychomotor coordination and mental ability, effects undocumented in Literature.

The aim of the investigators study was to assess whether the reversal with sugammadex after intraoperative continuous infusion of rocuronium, can improve the quality of awakening.

Enrollment: 120 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA score ≤ III
• Patients underwent robotic cystectomy

Exclusion criteria

• Cerebrovascular disease
• BMI ≥ 30

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

sugammadex

Active Comparator group

Description:

this arm will receive sugammadex at the end of the surgery

Treatment:

Drug: sugammadex

neostigmine

Active Comparator group

Description:

this arm will receive neostigmine at the end of the surgery

Treatment:

Drug: Neostigmine