Quality of Life and Functional Outcomes in Laryngeal Cancer Patients (QoL in LSSC)

Saglik Bilimleri Universitesi

Status: Not yet enrolling

Conditions: Anxiety Depression; Quality of Life (QOL); Patient Satisfaction; Pain Management; Laryngeal Carcinoma; Swallowing Function; Voice Quality

Treatments: Other: Voice Assessment; Other: Quality of Life Assessment; Other: Patient Satisfaction Assessment; Other: Pain Assessment; Other: Swallowing Function Assessment; Other: Anxiety and Depression Assessment

Study type: Observational

Funder types: Other

Identifiers

NCT07320820

Ankara Etlik City Hospital

SaglikBUniversity

Details and patient eligibility

About

Laryngeal squamous cell carcinomas are head and neck malignancies that directly affect both swallowing and voice functions and are associated with a significant deterioration in patients' quality of life throughout the treatment process.

The aim of this study is to evaluate quality of life, voice and swallowing functions, pain, anxiety-depression levels, and patient satisfaction at the pre-treatment period and at the 3rd, 6th, and 12th months post-treatment in patients with laryngeal malignancies, using validated questionnaires, in order to:

Elucidate the course of functional recovery following treatment,

Individualize rehabilitation and follow-up strategies, and

Examine the relationship between functional outcomes and oncological survival.

Enrollment: 120 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years at the time of enrollment.
• Histopathologically confirmed diagnosis of laryngeal squamous cell carcinoma.
• Planned to undergo surgical treatment or radiotherapy/chemoradiotherapy as part of standard oncological care.
• Willing and able to participate in the study and to provide written informed consent.
• No history of psychiatric or neurological disorders that could impair comprehension, questionnaire completion, or study participation.

Exclusion criteria

• Age < 18 years.
• Presence of comorbid conditions that may independently affect swallowing or voice functions.
• Patients who withdraw consent or request to discontinue participation during or after the treatment period.
• History of psychiatric disorders or use of psychiatric medications that may interfere with study participation or completion of patient-reported outcome measures.

Trial design

120 participants in 3 patient groups

Surgical Treatment Group

Description:

This group includes patients with laryngeal squamous cell carcinoma who undergo primary surgical treatment, such as partial or total laryngectomy, with or without neck dissection, in accordance with standard oncological indications. Patients in this group may receive adjuvant radiotherapy or chemoradiotherapy when clinically indicated based on pathological findings.

Treatment:

Other: Anxiety and Depression Assessment

Other: Pain Assessment

Other: Swallowing Function Assessment

Other: Patient Satisfaction Assessment

Other: Quality of Life Assessment

Other: Voice Assessment

Radiotherapy Group

Description:

This group consists of patients with laryngeal squamous cell carcinoma treated with definitive radiotherapy as the primary treatment modality. Radiotherapy is delivered according to established clinical protocols, and no surgical intervention to the primary tumor is performed as the initial treatment.

Treatment:

Other: Anxiety and Depression Assessment

Other: Pain Assessment

Other: Swallowing Function Assessment

Other: Patient Satisfaction Assessment

Other: Quality of Life Assessment

Other: Voice Assessment

Chemoradiotherapy Group

Description:

This group includes patients with laryngeal squamous cell carcinoma who receive concurrent chemoradiotherapy as the primary treatment modality, typically for organ preservation purposes or in locally advanced disease. Chemotherapy is administered concurrently with radiotherapy in accordance with institutional and international treatment guidelines.

Treatment:

Other: Anxiety and Depression Assessment

Other: Pain Assessment

Other: Swallowing Function Assessment

Other: Patient Satisfaction Assessment

Other: Quality of Life Assessment

Other: Voice Assessment