Quality of Life and Patient Needs in Advanced High Grade Gliomas

Henry Ford Health

Status: Completed

Conditions: Glioblastoma; Glioma; Brain Tumor; Quality of Life; Anaplastic Astrocytoma

Treatments: Other: Phone interviews

Study type: Observational

Funder types: Other

Identifiers

NCT05039346

IRB 14537

Details and patient eligibility

About

There is limited knowledge regarding the quality of life and needs of patients with advanced high grade gliomas, especially during the end of life. By doing this research, we are able to assess caregiver and patient symptoms and needs during the end of life phase of patients with brain tumors.

Full description

Purpose: This is a pilot study to prospectively assess the symptoms and quality of life of patients and with advanced high grade glioma and their care takers.

Specific Aims: The aim of this study is to investigate the symptoms of patients with advanced high grade glioma. Patients who failed 3rd line chemotherapy and who require at least occasional assistance will be prospectively followed and their symptoms will be prospectively assessed. Patient's caregiver will be interviewed following the death of the patient to assess clinical symptoms in the last weeks of life and around the time of death.

Methods: Patients will undergo clinical symptom assessment via questionnaire. Patients will be followed by regular semi-structured phone interviews.

Should a patient pass, four weeks following this, the patient's care giver will be interviewed.

Enrollment: 55 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age >18
• Tissue proven diagnosis of a high grade brain tumor
• Disease progression by MRI
• Therapy resistant tumor to 2nd line chemotherapy
• Karnofsky Performance Scale (KPS) score of 60 or less
• Patient will need to assign caregiver

Exclusion criteria

• None

Trial design

55 participants in 2 patient groups

Brain Tumor

Description:

Patients who are diagnosed with a high grade glioma that is progressive and therapy resistance. Patients will have a KPS of 60 or less.

Treatment:

Other: Phone interviews

Care Giver

Description:

Should a patient be unable to answer, the care giver will step in and provide surrogate answers. Additionally, at four weeks following the patient's death, the patient's care giver will be interviewed by utilizing a validated questionnaire.

Treatment:

Other: Phone interviews