Quality of Life in Barrett's Esophagus and Gastro-Esophageal Reflux Disease

Midwest Biomedical Research Foundation

Status: Terminated

Conditions: Gastroesophageal Reflux Disease; Barrett's Esophagus

Study type: Observational

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT01572974

PS0056

Details and patient eligibility

About

To Compare the overall quality of life of patients with no Barrett's esophagus , non-dysplastic Barrett's Esophagus (NDBE), Barrett's esophagus with low grade dysplasia (LGD), and Barrett's esophagus with high grade dysplasia (HGD). We also Compare the overall quality of life of Barrett's esophagus patients with severe gastroesophageal reflux disease (GERD) symptoms to those with no GERD symptoms

Full description

The presence of GERD symptoms is associated with a significant decrease in quality of life.While a diagnosis of Barrett's esophagus is also associated with a decrease in quality of life, these studies evaluated Barrett's esophagus patients with GERD symptoms.It is unclear whether decrements in quality of life from cancer risk in patients with Barrett's esophagus are due to actual cancer risk or a patient's false perception.Here we Compare the overall quality of life of patients with no Barrett's esophagus , non-dysplastic Barrett's Esophagus (NDBE), Barrett's esophagus with low grade dysplasia (LGD), and Barrett's esophagus with high grade dysplasia (HGD). The Investigators will also Compare the overall quality of life of Barrett's esophagus patients with severe gastroesophageal reflux disease (GERD) symptoms to those with no GERD symptoms. Finally the investigators will compare the overall quality of life of patients with a perceived low risk of esophageal cancer to those with a perceived high risk of esophageal cancer

Enrollment: 89 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Age 18 or above

At least one of the following:

Previous diagnosis of Barrett's esophagus Presence of GERD symptoms per patient report

Exclusion criteria

None

Trial design

89 participants in 4 patient groups

No Barrett's esophagus

Description:

Subject without columnar lined esophagus

Nondysplastic BE

Description:

Subject with columnar lined esophagus and absence of dysplasia

Low grade dysplastic BE

Description:

subject with columnar lined esophagus and presence of low grade dysplasia

High grade dysplastic BE

Description:

subject with columnar lined esophagus and presence of high grade dysplasia