Quality of Life in Children Glaucoma and Cataract

Moorfields Eye Hospital NHS Foundation Trust

Status: Completed

Conditions: Paediatrics With Glaucoma; Paediatrics With Cataracts

Treatments: Other: Quality of Life questionnaire

Study type: Observational

Funder types: Other

Identifiers

NCT02490267

DALA1020

Details and patient eligibility

About

The management of childhood glaucoma (CG), childhood cataract (CC) and other birth defects affecting the eyes requires frequent hospital attendances and often multiple surgical and medical interventions, and are often associated with poor vision. Chronic medical conditions and vision impairment can affect quality of life (QoL). The QoL of children with the above conditions has not previously been evaluated.

Full description

We wish to evaluate health related and vision related quality of life (HRQoL, VRQoL) in children age 2 to 16 years with childhood glaucoma (CG), childhood cataract (CC) and congenital eye defects microphthalmia, anophthalmia or coloboma (MAC).

We will recruit children who attend the children's eye clinics at Moorfields Eye Hospital at City Road. We will include the following subgroups:

A) children with primary or secondary glaucoma B) children with cataract or previously treated for cataract C) children with microphthalmia, anophthalmia or coloboma D) control group: agematched children without eye and vision problems. We will ask children and their carers to complete two age appropriate, validated questionnaires, the PedsQL (health related quality of life) and the Cardiff Visual Ability Questionnaire for Children. From the medical notes, we will record diagnosis and best corrected visual acuity with both eyes open. We will also record details of previous and current treatment, such as number of previous surgical interventions (sum of interventions right and left eye) and number of current topical medications (sum of eyedrop applications per day right and left eye).

Enrollment: 200 patients

Sex: All

Ages: 2 to 16 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

A) children with primary or secondary glaucoma B) children with cataract or previously treated for cataract C) children with microphthalmia, anophthalmia or coloboma D) control group: age-matched children without eye and vision problems

Exclusion criteria

• Ocular hypertension not requiring treatment; visually not significant cataract; inability to communicate in English; surgical intervention (incisional) within one month of potential date of completing questionnaire (before or after)

Trial design

200 participants in 4 patient groups

1

Description:

children with primary or secondary glaucoma

Treatment:

Other: Quality of Life questionnaire

2

Description:

children w/ cataract or previously treated for cataract

Treatment:

Other: Quality of Life questionnaire

3

Description:

children w/ microphthalmia, anophthalmia or coloboma

Treatment:

Other: Quality of Life questionnaire

control group

Description:

age matched children without eye and vision problems.

Treatment:

Other: Quality of Life questionnaire