Quality of the Management of Diabetes in Elderly People With Dementia in France (DIA-FRADEM)

Toulouse University Hospital

Status: Completed

Conditions: Alzheimer Disease

Treatments: Other: Incidence analysis

Study type: Observational

Funder types: Other

Identifiers

NCT03565809

RC31/16/8256

Details and patient eligibility

About

Along with population ageing, the association of chronic conditions such as Alzheimer's Disease and Related Syndromes (ADRS) and diabetes mellitus is increasing in clinical practice. According to ADRS severity, guidelines of diabetes care may be adapted for a personalized monitoring and treatment. The consequences on diabetes complications are not known and can also threaten dementia progression. Based on a nationwide healthcare reimbursement database, the present study aimed to compare diabetes care and the incidence of acute complications between patients with or without ADRS, in a longitudinal perspective focusing on the pivotal period of ADRS identification by the healthcare system.

Enrollment: 87,816 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• individuals with a first ADRS criterion in 2011 or 2012,
• prevalent diabetes mellitus, defined by a LTD with ICD-10 codes of diabetes mellitus ("E10-E14").
• at least one reimbursement in the year preceding inclusion.

Trial design

87,816 participants in 2 patient groups

Case : ADRS group

Description:

Incidence analysis in ADRS group defined by the first recording of one of the following criteria: (i) LTD registration for ADRS (ICD-10 codes: "F00-F03", "G30", or "G31"), (ii) hospital stay reporting a diagnosis code of ADRS (similar ICD-10 codes) or (iii) reimbursement for at least one acetylcholinesterase inhibitor (rivastigmine, galantamine or donepezil) or memantine.

Treatment:

Other: Incidence analysis

Control : non ADRS Group

Description:

Incidence analysis in non ADRS group. Each incident ADRS case was paired (1:1) to a beneficiary without any ADRS criteria, matched on age (same birth year), sex, residence area (based on of the 100 administrative 'départements') and insurance scheme.

Treatment:

Other: Incidence analysis