Quantification and Repeatability of Magnetic Stimulation

Federal Institute of Technology (ETH) Zurich

Status: Active, not recruiting

Conditions: Healthy

Treatments: Other: Magnetic phrenic nerve stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT05302752

REMEX-WP1

Details and patient eligibility

About

In this project the quantification and the repeatability of responses to rapid bilateral magnetic stimulation of the phrenic nerves will be investigated in healthy humans.

Enrollment: 16 patients

Sex: All

Ages: 18 to 39 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy
• non-smoking
• normal lung function
• body mass index: 18.5-29.9 kg/m2
• able to communicate in english
• willing to adhere to study rules

Exclusion criteria

• acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep
• intake of medications affecting metabolism, the cardiovascular, the neuromuscular or the respiratory system, or sleep
• any metal or electronics inside of the body
• presence of cardiac pacemaker, implanted defibrillators or implanted neurostimulators
• history of seizures or epilepsy
• tatoos on the stimulation sites
• previous enrolment in this study
• for women: pregnancy, breastfeeding, or intention to become pregnant during the study

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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16 participants in 1 patient group

Bilateral rapid magnetic stimulation of the phrenic nerves

Experimental group

Description:

Each participant will be tested on three different days with optimal settings for bilateral rapid magnetic stimulation of the phrenic nerves established on visit 1 and then repeated on visits 2 and 3.

Treatment:

Other: Magnetic phrenic nerve stimulation