Quantification & Classification of Inflammatory Cells in Uveitis Using OCT

Oregon Health & Science University (OHSU)

Status: Enrolling

Conditions: Sarcoidosis; Birdshot Chorioretinitis; Herpes Simplex Virus; Behcet Disease; Juvenile Idiopathic Arthritis (JIA); Anterior Uveitis (AU); Spondyloarthritis (SA); Posterior Vitreous Detachment

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT07065747

R21EY036563 (U.S. NIH Grant/Contract)

OHSU IRB0008052

Details and patient eligibility

About

The goal of this study is to determine if it's possible to use a high resolution imaging device called optical coherence tomography (OCT) to develop an unbiased, standard method of counting and categorizing the various types of cells and proteins found in an eye condition called anterior uveitis. Anterior uveitis is a type of inflammation in the eye that can be caused by many different diseases of the body.

Enrollment: 125 estimated patients

Sex: All

Ages: 5 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Uveitis Group: Eyes with active intraocular inflammation and a clinical diagnose of spondyloarthritis/HLA-B27 associated anterior uveitis, Juvenile Idiopathic Arthritis (JIA) associated chronic anterior uveitis, Herpes Simplex Virus (HSV) anterior uveitis, Birdshot chorioretinitis, Behcet disease uveitis, sarcoidosis associated uveitis, uveitis of any additional type, or uveitis masquerade.
2. Posterior Vitreous Detachment Group: Eyes with vitreous floaters and posterior vitreous detachment (PVD).
3. Healthy/Control Group: Healthy eyes with no history of uveitis, PVD, or previous eye surgery.

Exclusion criteria

1. Inability to give informed consent.
2. Inability to maintain stable fixation for OCT imaging.
3. Inability to commit to required visits to complete the study.
4. Pregnancy and breastfeeding.

Trial design

125 participants in 3 patient groups

Uveitis Group

Description:

Eyes with active inflammation due to various systemic diseases

Posterior Vitreous Detachment Group

Description:

Eyes with vitreous floaters and posterior vitreous detachment

Healthy/Control Group

Description:

Healthy eyes with no history of uveitis, posterior vitreous detachment, or previous eye surgery