Quantification of Abdominal Organ Motion Using MRI (QUANTUM)

The Christie NHS Foundation Trust

Status: Completed

Conditions: Cancer

Treatments: Device: Compression belt; Other: Visual Guided Breath-hold

Study type: Observational

Funder types: Other

Identifiers

NCT04748094

CFTSp166

Details and patient eligibility

About

The primary aim of the study is to quantify abdominal motion in order to optimise MR imaging. The study will compare three-motion management strategies a) free-breathing, b) using an abdominal compression belt and c) using MRI-compatible visually guided breath-holds.

Enrollment: 23 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Healthy volunteers

• 18 years or older,
• no MRI contra-indications
• must agree to registration as a non-patient in CWP (the local electronic healthcare records system) and have their MRIs read and reviewed for incidental findings by a clinical radiologist

Patient Volunteers

• undergoing radiotherapy to the abdominal region at the Christie NHS Foundation Trust
• Over 18 years of age

Exclusion criteria

• Any contraindications to MRI identified after MRI safety screening including completion of an MRI Safety Screening Form
• Unable to tolerate MRI scan
• Pregnancy
• Colostomy

Trial design

23 participants in 2 patient groups

Free-breathing versus Compression

Description:

This cohort of volunteers and patients will undergo imaging on the MR-Linac investigating free-breathing motion, and comparing it to motion using an abdominal compression device.

Treatment:

Device: Compression belt

Free-breathing versus Breath-holding

Description:

This cohort of volunteers and patients will undergo imaging on the MRSim investigating free-breathing motion and comparing it to visually-guided breath-hold motion (and reproducibility).

Treatment:

Other: Visual Guided Breath-hold