Quantification of Autonomic Nervous Activity During Hemodialysis

University of Hyogo

Status: Completed

Conditions: Chronic Kidney Disease on Hemodialysis

Treatments: Other: Analysis of the holter electrocardiogram

Study type: Interventional

Funder types: Other

Identifiers

NCT02754986

UHyogo

Details and patient eligibility

About

This study assesses autonomic nervous system function by power spectral analysis of RR interval dynamics in ultrafiltration subjects without blood pressure variation.

Full description

Variations over time in autonomic nervous activity due to differences in ultrafiltration rate will be evaluated by measuring heart rate variability in hemodialysis patients without blood pressure variations during HD session.

The subjects will be divided into 3 groups, those with UFR < 10 ml/hr/kg; ≥10 ml/hr/kg but ≤ 15 ml/hr/kg; and >15 ml/hr/kg, and Holter ECG are recorded continuously during HD session using frequency analysis of RR intervals.

Enrollment: 35 patients

Sex: All

Ages: Under 1 year old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with stable undergoing hemodialysis without hanging in blood pressure during hemodialysis.

Exclusion criteria

• Patients with chronic atrial fibrillation
• Patients with frequent ventricular premature beats
• Patients with a permanent pacemaker
• Patients with taking antihypertensive drugs
• Patients with medical treatment due to changes in blood pressure

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Single Blind

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35 participants in 1 patient group

measuring Holter electrocardiogram

Experimental group

Description:

Hotter ECG will be recorded continuously during hemodialysis

Treatment:

Other: Analysis of the holter electrocardiogram