Quantification of Hepatic Fibrosis by IVIM Sequences in 1.5T MRI (IVIM-MRI)

University Hospital, Clermont-Ferrand

Status: Unknown

Conditions: MRI; Liver Biopsy; IVIM; Liver Fibrosis

Treatments: Procedure: Quantification of liver fibrosis

Study type: Interventional

Funder types: Other

Identifiers

NCT03173287

CHU-327

2016-A02066-45 (Other Identifier)

Details and patient eligibility

About

Quantification of hepatic fibrosis by IVIM sequences in 1.5T MRI.

Full description

Early and accurate diagnosis of hepatic fibrosis in patients with chronic liver disease is essential and essential. This assessment could be performed by a non-invasive MRI method.

The main objective of this study is to show that the measured perfusion-related scattering value (D *) is related to the hepatic fibrosis stage.

Secondary objectives

• Evaluation of infusion fraction (f) and fibrosis stage.
• Evaluation of molecular diffusion (D) and fibrosis stage.
• Evaluation of ADC and fibrosis stage.
• Assess whether there is a link between the etiology of fibrosis and the value of the diffusion.

Enrollment: 63 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing hepatic biopsy (trans-parietal or trans-jugular) in the context of liver disease
• Signature of written consent

Exclusion criteria

• Contra-indications to MRI
• Refusal of protocol
• Underage patients and protected adults

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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63 participants in 1 patient group

Patients with hepatic biopsy

Experimental group

Description:

The patients having benefited from a hepatic biopsy for evaluation of the hepatic fibrosis, will benefit in 10 days of a MRI in the service of radiology of the hospital Gabriel Montpied.

Treatment:

Procedure: Quantification of liver fibrosis