Quantification of Microbiota in Health and Diseases (qMHD)

University of Catanzaro

Status: Unknown

Conditions: Disease

Treatments: Diagnostic Test: quantification of microbiota

Study type: Observational

Funder types: Other

Identifiers

NCT03388424

Microbiota2018

Details and patient eligibility

About

Microbiota consists of trillions of microorganisms located in all the biological cavity. The relationships between individual health status and microbiota are based on a sort of "mutual cooperation." The balance of the microbiota can be compromised by various factors such as environmental, psycho-physical stress, malnutrition (over or low), breastfeeding, chronic diseases, oncology and pharmacological treatments (especially antibiotics and chemotherapics). The impact of dysbiosis on today's society affects over 70% of the world population

Full description

Intestinal microbiota is defined as the strongest modulator of the human genome and it is considered the "second brain" of our organism for its bi-directional communication with the central nervous system. Microbiota consists of trillions of microorganisms located in all the biological cavity, In the intestine it is distributed in ecological niches having multiple metabolic activities which influence individual health. Microbiota acts as barrier against pathogens, regulating the absorption of nutrients, the production of energy and the development of the immune system4. Intestinal bacteria are generally divided into 4 Phylum: Firmicutes, Actinobacteria, Proteobacteria and Bacteriodetes, in which their proportion shows a correlation with individuals health status. When in equilibrium among them, these bacteria are essential for the good health of the digestive tract, the good function of immune system and for brain performace. The relationships between individual health status and microbiota are based on a sort of "mutual cooperation." The balance of the microbiota can be compromised by various factors such as environmental, psycho-physical stress, malnutrition (over or low), breastfeeding, chronic diseases, oncology and pharmacological treatments (especially antibiotics and chemotherapics). This disequilibrium leads to altered capability of bacteria to properly extract calories from food affecting the trend of many pathophisilogical status such as obesity, allergic states, inflammatory bowel syndromes cardiovascular diseases, metabolic, oncological and neurodegenerative diseases. The impact of dysbiosis on today's society affects over 70% of the world population

Enrollment: 120 estimated patients

Sex: All

Ages: 4 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• all patients will be enclosed in each group in agreement with the characteristics of the groups

Exclusion criteria

• Patients who will not sign the informed consent

Trial design

120 participants in 6 patient groups

Control

Description:

Healthy people of both sex

Treatment:

Diagnostic Test: quantification of microbiota

quantification of microbiota in Brain

Description:

Patients of both sex with neural disorders and diseases

Treatment:

Diagnostic Test: quantification of microbiota

quantification of microbiota in GI

Description:

Patients of both sex with gastrointestinal diseases

Treatment:

Diagnostic Test: quantification of microbiota

quantification of microbiota in Lung

Description:

Patients of both sex with Respiratory diseases

Treatment:

Diagnostic Test: quantification of microbiota

quantification of microbiota Metabolic

Description:

Patients of both sex with Metabolic Diseases

Treatment:

Diagnostic Test: quantification of microbiota

quantification of microbiota in UG

Description:

Patients of both sex with Uro-genital Diseases

Treatment:

Diagnostic Test: quantification of microbiota