Quantification of Nerve Stiffness in Neuropathies (Nerf_SSI)

Nantes University Hospital (NUH)

Status: Completed

Conditions: Anti-MAG Neuropathy; Chronic Inflammatory Demyelinating Polyneuropathy; Charcot-Marie-Tooth Disease, Type IA

Treatments: Other: elastography measurements

Study type: Interventional

Funder types: Other

Identifiers

NCT03397303

RC17_0231

Details and patient eligibility

About

This project aims to understand how nerve mechanical properties are altered in patients with rare peripheral neuropathies . Stiffness of various peripheral nerves will be measured using ultrasound shear wave elastography. Patients will be compared with age-matched controls.

Full description

The following nerve will be studied bilaterally, in a randomised order: Median, ulnar, Radial, Sciatic and Tibial.

Participants will be asked to remain relaxed during elastography measurements.

Enrollment: 36 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male or female aged 18 to 65
• Having social insurance status
• Having given informed consent
• Diagnostic of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), CMT1a or Anti-MAG (peak immunoglobulin M (IGm)>15,000 BTU)

Exclusion criteria

For controls:

• Person staying in a health or social facility
• Person unable to understand the protocol and to respect the modalities
• Person deprived of liberty
• Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice)
• Participation in another biomedical research in progress
• Diabetes, history of neuromuscular disease

For CIDP:

• Person staying in a health or social facility
• Person unable to understand the protocol and to respect the modalities
• Person deprived of liberty
• Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice)
• Participation in another biomedical research in progress
• MRC score < 3

For Charcot-Marie-Tooth type 1 (CMT1) and anti-MAG:

• Person staying in a health or social facility
• Person unable to understand the protocol and to respect the modalities
• Person deprived of liberty
• Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice)
• Participation in another biomedical research in progress

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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36 participants in 2 patient groups

patients with peripheral neuropathies

Experimental group

Description:

This project aims to understand how nerve mechanical properties are altered in patients with rare peripheral neuropathies . Stiffness of various peripheral nerves will be measured using ultrasound shear wave elastography. Patients will be compared with age-matched controls.

Treatment:

Other: elastography measurements

controls

Other group

Treatment:

Other: elastography measurements