Quantification of Thrombocytes Number and Function in Patients Undergoing Prolonged Extracorporeal Circulation (CPB-PLT-FNCT)

Rambam Health Care Campus

Status: Unknown

Conditions: Coagulopathy

Study type: Observational

Funder types: Other

Identifiers

NCT02771223

15-645

Details and patient eligibility

About

Prolonged extracorporeal circulation (ECC) for cardiac surgery results in coagulation abnormalities, most of which related to the direct, time dependent effect of the polymer tubing and the pump rollers on the thrombocytes. Significant evidence demonstrates the effect of the duration of cardiopulmonary bypass on thrombocytes number and function, as well as on postoperative coagulopathy

Full description

Quantification of the effect of ECC duration on blood coagulation and platelet number and function

• Observational study on 20 patients undergoing prolonged ECC
• Blood sampling every 30 minutes for platelet count, platelet adhesion markers and coagulation studies
• Blood test to be performed in Rambam Blood Bank Laboratory

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adults over 18 yo
• scheduled for prolonged cardiac surgery requiring ECC time over 3 hours

Exclusion criteria

• documented coagulopathy
• antiplatelet therapy other then aspirin

Trial design

20 participants in 1 patient group

Study group

Description:

patients scheduled for prolonged cardiac surgery (over 3 hours anticipated ECC time) with no known coagulation disorders