Quantification of Transition Metals

University of Cologne

Status: Unknown

Conditions: Neurodegenerative Diseases; Infections

Study type: Observational

Funder types: Other

Identifiers

NCT02222779

KPUK-14-Metal

Details and patient eligibility

About

In this trial, concentrations of transition metals of interest are quantified in surplus cerebrospinal fluid (CSF) and blood serum samples. Quantification of the transition metals will be performed by inductively coupled plasma mass spectrometry (ICP-MS). The treating physicians as well as the patients will not be informed about the results of drug concentrations.

Full description

Samples used include:

Remaining portions of samples collected for diagnostic or therapeutic reasons (paired CSF and blood serum samples). No lumbar puncture will be done specifically for this protocol.

The objective of this study is to gain an overview about transition metals concentrations in blood serum and CSF in order to provide preliminary data on patients. The effect of neurodegenerative diseases on metals or the other way round will be assessed if possible.

Enrollment: 3,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: •

• The trial will include any patient (with various diseases, especially neurodegenerative diseases) who received a lumbar puncture.

Exclusion Criteria:

• • The lower age limit is 18 years. In concordance with the objective of the project there is no specific exclusion criteria.

Trial design

3,000 participants in 4 patient groups

Patients with Parkinson´s Disease

Patient´s with Alzheimer´s Disease

Patients with Multiple Sclerosis

Patients with any other neurodegenerative diseases