Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia
Status
Enrolling
Conditions
Dystonia
Deep Brain Stimulation
Motor Development
Pediatric
Treatments
Device: DBS
Details and patient eligibility
About
The goal of this study is to understand the development and progression of childhood dystonia, a movement disorder, in children. The main questions it aims to answer are:
How does the activity of the neural network evolve in children with dystonia in the context of motor development? What are the effects of chronic and active stimulation on cortical and subcortical motor network function in children with deep brain stimulation (DBS)?
Participants will:
- Undergo noninvasive electrophysiological measurements (EEG, EMG) to quantify neural network activity. They will be tested at rest and during a simple motor reaction task.
- Children with DBS will be assessed in the on and off DBS state to assess effects of chronic and active changes in motor network function.
Enrollment
75 estimated patients
Sex
All
Ages
6 to 21 years old
Volunteers
Accepts Healthy Volunteers
Inclusion criteria
- For dystonia subjects:
- Dx of dystonia (with and without DBS)
- willingness and ability to complete study protocols.
- For Typically Developing Controls:
- normal developmental milestones
- absence of any neuropsychiatric disorder
- no significant medical condition.
Exclusion criteria
- history of epilepsy
- presence of implanted medical devices (except DBS in dystonia subjects)
- lack of cognitive or physical ability to complete study protocol.
Trial design
Primary purpose
Diagnostic
Allocation
N/A
Interventional model
Single Group Assignment
Masking
None (Open label)
75 participants in 1 patient group
DBS
Experimental group
Description:
Patients with DBS will complete neurophysiological recordings with DBS on and off
Treatment:
Device: DBS
Trial contacts and locations
1
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Data sourced from clinicaltrials.gov
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