Quantifying Nitrous Oxide Effect on Depth of Anaesthesia Using Theoretically Based Time Series Modelling

Melbourne Health

Status and phase: Completed; Phase 4

Conditions: Depth of Anaesthesia

Treatments: Drug: Nitrous oxide

Study type: Interventional

Funder types: Other

Identifiers

NCT00226837

2004.109

Details and patient eligibility

About

Our hypothesis is that a new method of depth of anaesthesia monitoring, using theoretically based time series modelling will result in improved ability to determine nitrous oxide anaesthetic effect

Full description

We randomised patients to 0% 33% or 66% nitrous oxide during sevoflurane induction and measured anesthetic endpoints.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 18 years or older
• Presenting for surgery under general anaesthesia

Exclusion criteria

• Poor English language comprehension
• Risk of reflux
• Epilepsy or other EEG abnormality

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 3 patient groups, including a placebo group

1

Placebo Comparator group

Description:

0% nitrous oxide

Treatment:

Drug: Nitrous oxide

2

Active Comparator group

Description:

33% nitrous oxide

Treatment:

Drug: Nitrous oxide

3

Active Comparator group

Description:

66% nitrous oxide

Treatment:

Drug: Nitrous oxide