Quantifying Patient-Specific Changes in Neuromuscular Control in Cerebral Palsy
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About
Impaired neuromuscular control hinders movement for individuals with cerebral palsy and other neurological disorders. In this research, the investigators are developing new tools to quantify impaired neuromuscular control in cerebral palsy and evaluate changes after one of the most common treatments, orthopaedic surgery. The results from this research will empower clinicians to identify patient-specific factors that contribute to impaired movement and improve treatment and quality of life.
Full description
The long-term goals of this research are to quantify patient-specific changes in neuromuscular control in order to optimize treatment planning and improve mobility for individuals with cerebral palsy (CP). As a first step, the aims of this proposal are to evaluate neuromuscular control before and after one of the most common treatments for individuals with CP, orthopaedic surgery. The investigators will evaluate if patient-specific measures of neuromuscular control, based upon the framework of muscle synergies, can predict improvements in walking ability after surgery. Further, investigators will determine whether neuromuscular control changes after surgery and if these changes contribute to improvements in movement. To achieve these goal the investigators will implement and test new tools to quantify neuromuscular control which integrate clinical gait analysis and two computational techniques: synergy analysis and dynamic musculoskeletal simulation. This research will provide the foundation to use measures of altered neuromuscular control to inform treatment planning, develop alternative treatments, and improve mobility in CP and other neurologic disorders.
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Inclusion criteria
- Diplegic cerebral palsy
- Mild or Moderate Impairment, Gross Motor Function Classification System (GMFCS) Levels I-III
- Will receive follow-up care and physical therapy within the Gillette Children's Specialty Healthcare system
Exclusion criteria
- Botulinum toxin injections, baclofen, or other similar treatments in the 3 months prior to pre-operative gait analysis
Trial design
55 participants in 1 patient group
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Data sourced from clinicaltrials.gov
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