Quantifying Skin Oxygenation Properties in Normal vs Sun Exposed Skin (SMARTevans)

Mass General Brigham

Status

Terminated

Conditions

Healthy

Sun Exposure

Treatments

Device: Measurement of skin oxygenation and oxygen consumption

Study type

Observational

Funder types

Other

Industry

Identifiers

NCT03311191

2017P000695

Details and patient eligibility

About

This research study aims to determine if there are differences in oxygen consumption between chronically sun exposed and less sun exposed skin. This study uses a new imaging device that can detection oxygenation properties skin in a non-invasive manner.

Full description

Sun and ultraviolet light exposure has both short term and long term effects on skin. While the short term effects, such as sunburn, are understood, chronic long-term sun exposure can cause changes to the skin that are not well characterized. One particular alteration may be how the skin consumes oxygen, a change that may be linked to biochemical alterations that have been observed in past studies. Measuring skin oxygen consumption has traditionally been difficult as the tools available have not been easy to incorporate into clinical studies. In this study, we overcome this barrier through the use of a new non-invasive oxygen-sensing device that can rapidly measure skin oxygenation properties such as oxygen consumption. This observational study will measure the oxygenation properties of both chronically sun exposed and less sun exposed skin in the predefined groups of both young and older men and women.

Enrollment

11 patients

Sex

All

Ages

20 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Male or female
Age groups: 20 - 30 and 55 - 65
Fitzpatrick skin types I, II, III, and IV

Exclusion criteria

Fitzpatrick skin types V and above
Tattoo markings anywhere on the arm(s)
Significant scarring or discoloration (e.g. birthmarks) on the arm(s)
Any current injuries, infections or wounds on the arm(s)
Routinely (4+ doses per week) take high dosages of anti-inflammatory drugs (e.g. aspirin, ibuprofen, corticosteroids), immunosuppressive drugs, or antihistamine medications. However steroid nose drops and/or eye drops are permitted.
Has taken an anti-inflammatory drug (e.g. aspirin) within the prior 24 hours of the study visit.
Have diabetes that is treated with injectable or oral insulin
Have any other active or chronic skin problems on the arms
Are currently participating in another skin care product study at this or any other facility
Have participated in any type of skin product treatment study within the past 2 weeks
Have or ever have had dermatographia
Pregnant women
Lactating women