Quantitation of Glymphatic Functioning in Sleep and Meditative States

Vanderbilt University Medical Center

Status: Completed

Conditions: Parkinson Disease; Sleep

Treatments: Behavioral: Meditation

Study type: Interventional

Funder types: Other

Identifiers

NCT04506892

RFA-AT-21-001

Details and patient eligibility

About

This involves development and application of magnetic resonance imaging (MRI) methods for visualizing hemodynamic and metabolic relationships in healthy volunteers with advanced meditation experience.

Full description

This study is evaluating the glymphatic system during awake, sleep, and meditative states.

Enrollment: 75 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Ages 14-45
• "Adept meditator status"

Exclusion criteria

• Any non-MR compatible material implant, or contraindication to MR scanning
• Claustrophobia or inability to lie still for prolonged periods of time
• Participants with a recent (less than 2 months) infection, tattoo, or wound
• No consumption of stimulants or alcohol within 12 hours of the study visit
• clinical diagnosis of any major neurological or psychological condition
• Taking benzodiazepines, cholinestorase inhibitors, anti-psychotics, opioids, MAO inhibitors

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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75 participants in 1 patient group

Adept Meditators

Experimental group

Description:

Subjects will undergo scanning during awake, sleep deprived, and meditative states of consciousness.

Treatment:

Behavioral: Meditation