Quantitative Analysis of Global Proteome in Bone Samples From Patients With Osteoporotic and Nonosteoporotic Fracture

S

Soochow University

Status

Unknown

Conditions

Femoral Neck Fractures

Treatments

Procedure: total hip arthroplasty

Study type

Interventional

Funder types

Other

Identifiers

NCT03428672
Xu youjia 003

Details and patient eligibility

About

RATIONALE: Collecting and storing bone samples from patients with osteoporotic and nonosteoporotic fracture to quantitatively analyze the differentially expressed proteins to further explain the relationship between bone iron content and bone mineral density (BMD). PURPOSE: This research study is looking at changes of iron content and differentially expressed proteins in bone samples from patients with osteoporotic and nonosteoporotic. fracture.

Full description

OBJECTIVES: Establish the iron content in bone specimen in patients with hip fracture. Explore the correlation of BMD and differentially expressed proteins. OUTLINE: Collect human bone specimens from patients with osteoporotic and nonosteoporotic Fracture. Provide a repository for storage of tissue and make these specimens available for approved projects by laboratory-based investigators. Collect clinical data on these patients including bone mineral density. To examine the bone iron content using ICP/MS. Investigate the differentially expressed proteins through quantitative analysing the global proteome of osteoporotic and nonosteoporotic fracture bone specimens.

Enrollment

100 estimated patients

Sex

Female

Ages

55 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Ages Eligible for Study: 55-90 Years
  • Genders Eligible for Study: Woman
  • Accepts Healthy Volunteers: NO
  • Study Population: Female patients with hip fracture.

Exclusion criteria

  • Malignancy or benign ovarian cysts
  • Known chronic or systemic diseases
  • Hormone therapy in the previous 3 months
  • Bone metabolism and drug therapy

Trial design

Primary purpose

Diagnostic

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

100 participants in 2 patient groups

osteoporotic fractures
Experimental group
Description:
patients with osteoporotic fractures, including femoral neck fracture and pertrochanteric fracture. Total hip arthroplasty or proximal femoral nails was needed.
Treatment:
Procedure: total hip arthroplasty
nonosteoporotic fractures
Sham Comparator group
Description:
patients with nonosteoporotic fractures, including femoral neck fracture and pertrochanteric fracture. Total hip arthroplasty or proximal femoral nails was needed.
Treatment:
Procedure: total hip arthroplasty

Trial contacts and locations

0

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Central trial contact

Fan Yang, MSc; Youjia Xu, PhD

Data sourced from clinicaltrials.gov

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