Quantitative Analysis of Precise Brain Volume in Amyotrophic Lateral Sclerosis

Peking University

Status: Completed

Conditions: Amyotrophic Lateral Sclerosis

Treatments: Diagnostic Test: Diagnostic criteria

Study type: Observational

Funder types: Other

Identifiers

NCT04952025

M2020369

Details and patient eligibility

About

Using the original MRI images of 16 ALS patients and 16 normal controls matched by gender, age and education level in the previous study, the differences of brain volume in different parts of ALS patients and normal controls, and the correlation between brain structure and clinical characteristics were compared by precise brain volume quantitative analysis technology.

Full description

This study was a retrospective study. The subjects were 16 ALS patients and 16 normal controls. Previous studies have collected patients' age, gender and education level; The onset site, onset time, bulbar involvement, diagnostic grade, ALSFRS-R score, application of ventilator, application of lirutai, gastrostomy; Age, gender and education level were collected in the control group. Accurate quantitative analysis of brain volume was performed on the original brain MRI images of the two groups.

Enrollment: 32 patients

Sex

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed ALS patients
• healthy volunteers

Exclusion criteria

• none

Trial design

32 participants in 2 patient groups

ALS patients

Treatment:

Diagnostic Test: Diagnostic criteria

normal controls