Quantitative Determination of Brain Water Content in Patients During and After Hepatic Encepalopathy
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There is increasing evidence that the pathophysiology of hepatic encephalopathy (HE) is tightly associated with low-grade cerebral edema. Uptake of ammonia in astrocytes leads to osmotic swelling caused by glutamine formation. Previous studies were performed in covert HE patients or used indirect methods.
Methods: The investigators wish to describes quantitative measurement of localized water content using MRI water mapping in a cohort of patients with cirrhosis during an episode of overt HE type C and again after recovery. Furthermore patients with cirrhosis and no history of HE and healthy subjects will be investigated as controls.
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Inclusion criteria
- Patients with type C HE during and after HE,
- Patients with stable cirrhosis and
- Healthy subjects
Exclusion criteria
- Patients with pace-maker
- Metal implants
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Data sourced from clinicaltrials.gov
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