Quantitative Imaging and Proton Spectroscopy in Multiple Sclerosis

NYU Langone Health

Status: Terminated

Conditions: Multiple Sclerosis

Treatments: Device: Magnetic Resonance Imaging

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT01226654

9812

2R01NS029029-16A1 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The primary purpose of this study is to detect changes in the brain that may be associated with multiple sclerosis. Results will be compared to age matched controls. Investigators will assess lesions by measuring T2 and T1 enhanced lesion volumes and magnetization transfer ratio histogram parameters (MTRHP) in patients with relapsing-remitting and secondary-progressive disease. This data will be correlated to total brain parenchymal volume as well as identifying the effect of MS lesions on the gray and white matter, volumetric disability, including Kurtzke Expanded Disability Status Scale (EDSS) and a specific battery of neuropsychological tests. Quantitative analysis of whole brain N-acetylaspartate (WBNAA), a reproducible measure of viable neuron number, using 1H MRS and compare the results to age-matched controls over duration of 5 years.

Enrollment: 69 patients

Sex: All

Ages: 7 to 110 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Patients with known MS diagnosis
2. Age 7-110 years
3. Males or females

Exclusion criteria

1. Medically unstable
2. Artificial implants in the body
3. Pregnant

Normal Controls

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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69 participants in 2 patient groups

MS Patients

Other group

Description:

All subjects enrolled in this study will undergo MRI studies. A computerized neuropsychological battery of tests will be administered.

Treatment:

Device: Magnetic Resonance Imaging

Healthy Patients

Other group

Description:

Patients enrolled in this study will undergo MRI studies. A computerized neuropsychological battery of tests will be administered.

Treatment:

Device: Magnetic Resonance Imaging