Quantitative Sensory Testing and PET/CT Scanning in Assessment of Surgical Outcome for Lumbar Disc Herniation (PET-Pain)

Spine Centre of Southern Denmark

Status: Completed

Conditions: Radiculopathy Lumbar; Lumbar Disc Herniation

Treatments: Diagnostic Test: Quantitative Sensory Testing; Diagnostic Test: PET/CT scan

Study type: Interventional

Funder types: Other

Identifiers

NCT03894943

S-20140052

Details and patient eligibility

About

Patients with lumbar disc herniation suffer from pain and morbidity. Surgical intervention can be a quick and effective relief, however some individuals experience less favorable outcome.

This study tries to investigate and test the differences in pain perception and pain modulation between individuals. Using PET/CT scans the investigators try to visualize pain perception and -modulation in the CNS. This is subsequently correlated with a battery of pain tests and the surgical outcome of disc herniation surgery.

Enrollment: 61 patients

Sex: All

Ages: 40 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Informed consent
• Clinical and radiological indication for LDH surgery, assessed by an experienced spinal surgeon
• Age 40-65 years
• Able to comply with regulations regarding medicine consumption (stated below)

Exclusion criteria

• History of previous spine surgery
• General contra-indication for spine surgery
• Greatly reduced kidney function
• Diagnosis of psychiatric disorder
• Current malignant disease
• History of radiation therapy
• Current chemotherapy
• History of spinal fracture
• Hematologic disease
• Current pregnancy or breast-feeding
• Chronic, generalized connective tissue disorders or chronic, non-specific pain disorders (fibromyalgia, whiplash (WAD I-V), etc.)

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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61 participants in 1 patient group

General

Experimental group

Description:

All subjects will undergo ordinary surgical treatment for their lumbar disc herniation. Experimentally, all subjects participating in the study will receive PET/CT scans and sensory testing as specified below.

Treatment:

Diagnostic Test: Quantitative Sensory Testing

Diagnostic Test: PET/CT scan