Quebec Lung Cancer Screening PLUS Trial (QLC+)

Nicole Ezer, MD, FRCPC, MPH

Status: Active, not recruiting

Conditions: COPD; Coronary Artery Calcification

Treatments: Behavioral: Educational material and treatment recommendations for patients, general practitioners and pharmacists

Study type: Interventional

Funder types: Other

Identifiers

NCT05444062

MP-37-2023-8641

Details and patient eligibility

About

Does an educational intervention for untreated COPD and cardiovascular disease which is integrated in an existing lung cancer screening program improve guideline concordant medication adherence at 12 months

Enrollment: 330 estimated patients

Sex: All

Ages: 55 to 74 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient screened for lung cancer as part of the Quebec Lung Cancer Demonstration project by low dose CT scan of the chest.
• Cardiovascular aim: mild to severe CAC identified on low dose CT, not on guideline recommended lipid-lowering therapy.
• COPD aim: diagnosed with COPD, symptomatic (mMRC >=1 or CAT>= 10) and untreated, or not on first line guideline recommended therapy for COPD.

Exclusion criteria

• Any participant with a high suspicion of lung cancer, defined as Lung-RADS (Lung Imaging Reporting and Data System) 3 or 4, as this is an inopportune time to initiate new medical therapies.
• Cardiovascular aim: Absent CAC, known clinical atherosclerosis, known former heart surgery, Diabetes Mellitus.
• COPD aim: asymptomatic, or already on appropriate first line COPD therapy.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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330 participants in 4 patient groups

Control Arm: CVD

No Intervention group

Description:

Patients diagnosed with mild to severe CAC and not on first line guideline recommended therapy. Coronary artery Calcification (CAC) score obtained from lung cancer screening CT Scan images

Intervention Arm: CVD

Other group

Description:

Patients diagnosed with mild to severe CAC and not on first line guideline recommended therapy. CAC score obtained from lung cancer screening CT Scan images

Treatment:

Behavioral: Educational material and treatment recommendations for patients, general practitioners and pharmacists

Control Arm: COPD

No Intervention group

Description:

Patients with untreated COPD or not on first line guideline recommended therapy.

Intervention Arm: COPD

Other group

Description:

Patients with untreated COPD or not on first line guideline recommended therapy.

Treatment:

Behavioral: Educational material and treatment recommendations for patients, general practitioners and pharmacists