Quest to Analyze One Thousand Humans Meditating (QUANTUM)

Tobias Moeller-Bertram

Status: Invitation-only

Conditions: Eczema; Chronic Obstructive Pulmonary Disease (COPD); Cancer, Lung; Infertility; Cancer Prostate; Cancer Colon; Cancer, Other; Migraine; Lymphoma; Deafness; Psoriasis; Cancer, Breast; Lyme Disease; Chronic Fatigue Syndrome; Cancer, Thyroid; Amyotrophic Lateral Sclerosis (ALS); Cancer Skin; Atrial Fibrillation; Post Traumatic Stress Disorder (PTSD); Sjogrens Disease; Angina, Stable; Cancer, Ovarian; Ulcerative Colitis; Depression; Rheumatoid Arthritis; Throat Cancer; Fibroids; Cancer Brain; Tension Headache; Ovarian Cysts; Hypothyroidism; Tinnitus; Multiple Allergies; Osteoarthritis; Diabetes; Multiple Sclerosis; Parkinson Disease; Crohn Disease; Osteoporosis; Fibromyalgia; Chronic Kidney Diseases; Stroke; Cerebral Palsy; Heart Failure; Anxiety; Cluster Headache; Hypertension; Asthma; Epilepsy; Macular Degeneration; Hyperthyroidism; Spinal Stenosis; Phantom Limb Pain; Irritable Bowel Syndrome (IBS); Spinal Cord Injury

Treatments: Behavioral: Advanced multi-component meditation practice

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT06583395

20211477A

Details and patient eligibility

About

This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and clinical populations.

Full description

Meditation and other mind-body interventions (MBIs) have been shown to have a range of health benefits, including an improved stress response, a reduction in inflammatory processes, and an enhanced innate immune response. While several studies on MBIs have been carried out to assess metabolomic, transcriptomic, epigenomic, or physiological outcomes, comprehensive studies including all of these components have not been reported. In addition, most studies have been small, comprised of less than 100 research subjects.

One particular area of meditation research that remains largely unexplored is the gut. A bi-directional communication occurs between the gut and the brain, thus, the gut microbiota can influence behavior, resulting in psychosocial stress and negatively impacting the microbiome. One would predict, then, that meditation-based reductions in stress would have positive effects on gut microbial makeup. Importantly, diseased states are characterized by specific gut microbiome profiles, thus, one can use the microbiome to assay for meditation-induced changes in these states.

In this study, a comprehensive multi-omic analysis will be carried out to determine the effect of an immersive 7-day meditation experience in a retreat setting in a large 2000+ person cohort. Metagenomic analysis will be performed on the gut microbiome, including healthy and clinical populations, to assess disease-specific improvements (Phase 1). In addition, Garmin wearable technology will be used to collect biometric health data, including heart rate, sleep, stress, and activity, for up to 10 months after the meditation retreat (Phase 1). In Phase 2 of this study, the biological analyses will be expanded to include blood and urine. Taken together, these data will be coupled with self-report surveys of physical and emotional health and integrated into a machine-learning platform to assess microbiome shifts tied with epigenetics, proteomics, metabolomics, transformational language, and improvements in health.

The advanced week-long meditation retreat will include approximately 25 hours of instruction and 35 hours of meditation. The meditations will include elements of focused attention, non-dual awareness, and loving kindness compassion techniques. While these meditations are unique to this meditation teacher, they are centered around Kundalini and Vipassana techniques. The meditations will be carried out seated, standing, lying down, and walking. The retreat setting allows for controlling many variables, including sleep schedule, meditation schedule, and diet.

Enrollment: 3,000 estimated patients

Sex: All

Ages: 21+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Must be at 21 years of age or older
2. Must speak English
3. Must be a registered attendee of the advanced 7-Day meditation retreat
4. Must be willing to wear a Garmin device for the entire retreat
5. Must complete the research consent to participate in the study
6. Must be willing to complete self-report surveys for physical and emotional well-being

Exclusion criteria

1. Younger than 21 years of age
2. Non-English speaking
3. Not a registered attendee of the advanced 7-Day meditation retreat
4. Not willing to wear a Garmin device for the entire meditation retreat
5. Did not complete the research consent
6. Not willing or able to complete all self-report surveys

Trial design