Quetiapine Augmentation Versus Clomipramine Augmentation of SSRI for Obsessive-compulsive Disorder Patients (QCAT)

University of Sao Paulo

Status and phase

Completed

Phase 4

Conditions

Obsessive Compulsive Disorder

Treatments

Drug: Clomipramine

Drug: Quetiapine

Study type

Interventional

Funder types

Other

Identifiers

NCT00564564

2005/55628-08 (Other Grant/Funding Number)

968/05

Details and patient eligibility

About

The objective of this trial is to compare in an open trial format the efficacy of association of clomipramine and quetiapine with SSRI after SSRI treatment failed to produce complete remission of obsessive compulsive disorder symptoms.

Full description

The objective of this trial wis to compare in an randomized open trial format the efficacy of association of clomipramine at maximum dosage of 75mg per day and quetiapine at maximum dosage of 200mg per day with SSRI after SSRI treatment for 12 weeks failed to produce complete remission of OCD symptoms.

Enrollment

21 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

primary OCD diagnosis according to DSM IV criteria
current symptoms were responsible for significant distress
previous trial of at least 12 weeks with SSRI (being at least 8 weeks at maximum tolerated dosage) failed to produce full remission of OCD symptoms

Exclusion criteria

presence of clinical or neurological diseases that may be worsen by the medications included in treatment protocol
current substance dependence or abuse,
current psychotic symptoms
current suicide risk
and current pregnancy or intention to get pregnant before the end of the treatment protocol