QUILT-3.025: A Phase 2 Study of AMG 479 in Relapsed or Refractory Ewing's Family Tumor and Desmoplastic Small Round Cell Tumors

NantCell

Status and phase: Completed; Phase 2

Conditions: Estraosseous Ewing's Tumor; Sarcoma; Ewing's Sarcoma; Primitive Neuroectodermal Tumors (PNETs); Askin's Tumors; Desmoplastic Small Round Cell Tumors; Ewing's Family Tumor

Treatments: Drug: AMG 479

Study type: Interventional

Funder types: Industry

Identifiers

NCT00563680

20060283

QUILT-3.025 (Other Identifier)

Details and patient eligibility

About

Single-arm, open-label study of AMG 479 in up to 35 subjects with Ewing's Family Tumors (EFTs) and Desmoplastic Small Round Cell Tumors (DSRCTs) who have progressed or recurred after at least one prior chemotherapy regimen. An exploratory cohort of an additional up to 10 subjects with prior exposure to anti-IGF-1R therapy and who have progressed or recurred after at least one prior chemotherapy regimen will also be assessed.

Enrollment: 38 patients

Sex: All

Ages: 16+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Male and female subjects ≥ 16 years of age with a diagnosis of EFT or DSRCT who have relapsed or progressed after at least one prior chemotherapeutic regimen will be eligible for this study.

Before any study-specific procedure, the appropriate written informed consent must be obtained.

Inclusion Criteria:

Disease Related Subjects with pathological or histological diagnosis of Ewing's Family Tumor or Desmoplastic Small Round Cell Tumor.

• Measurable disease as defined by RECIST.
• Documented failure of at least one prior chemotherapy regimen for their disease.
• Eastern Cooperative Oncology Group (ECOG) Performance Status ≤ 2.

Demographic

• Males or females ≥ 16 years old.
• Signed written informed consent.
• Able to comply with visits and procedures.

Laboratory

• Willing to provide existing and/or newly acquired tumor samples.
• Diabetic Subjects (Type 1 or 2) must have HgbA1c < 8.0% and fasting blood glucose level < 160 mg/dL.

General

• Must be willing and able to use birth control (double barrier protection or abstinence) during and for 6 months after the study
• Prior exposure to another anti-IGF-1R therapy will only be allowed for a limited number of additional subjects (up to 10) in an exploratory cohort

Exclusion Criteria

Disease Related

• Known brain metastasis.
• History of bleeding diathesis.
• History of another malignancy.
• History of chronic hepatitis.
• Documented prior history of human immunodeficiency virus.

Laboratory

• Absolute neutrophil count < 1.5 x109/L.
• Platelet count < 100 x 109/L.
• Hemoglobin < 9 g/dL.
• PT > 1.5 x institutional upper limit of normal (IULN) or PTT > 1.0 x IULN.
• Serum creatinine > 1.5 x IULN.
• Aspartate aminotransferase (AST) > 2.5 x IULN or Alanine aminotransferase (ALT) > 2.5 x IULN (> 5.0 x if liver metastases present).
• Total bilirubin > 1.5 IULN (> 3.0 x with documented Gilbert's Syndrome)

Medication

• Antitumor treatment within 21 days of Study Day 1.
• Anticoagulation therapy within 28 days of Study Day 1.
• Major surgery within 28 days of Study Day 1.

General

• Other investigational procedures are excluded.
• Inability to tolerate intravenous administration.
• Subject is pregnant (eg, positive HCG test) or is breast feeding.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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38 participants in 2 patient groups

Exploratory Cohort

Experimental group

Description:

If a total of two or more responses (partial and complete) in EFTs/DSRCTs are documented in this or the ongoing phase 1 study (20050118), then the study will allow enrollment of up to 10 additional EFT/DSRCT subjects who have been exposed to prior anti-IGF-1R targeting therapy.

Treatment:

Drug: AMG 479

Main Cohort

Experimental group

Description:

Subjects with relapsed Ewing's Family Tumors (EFTs) and Desmoplastic Small Round Cell Tumors (DSRCTs) who have not received prior anti-IGF-1R therapy will receive AMG 479 at 12mg/kg.

Treatment:

Drug: AMG 479