R-3750 in Patients With Mild to Moderate Ulcerative Colitis

Rise Therapeutics

Status and phase

Enrolling

Phase 1

Conditions

Ulcerative Colitis Chronic Mild

Ulcerative Colitis Chronic

Ulcerative Colitis

Ulcerative Colitis Chronic Moderate

Treatments

Drug: R-3750

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT05666960

RISE R-3750-01

Details and patient eligibility

About

The goal of this study is to determine the safety and tolerability of orally taken probiotic (R-3750) in patients with mild to moderate ulcerative colitis.

Patients will take an oral dosage of probiotic (R-3750) and provide patient-reported and physician scored measures of their colitis. Blood and fecal evaluations of inflammation and assessment of probiotic (R-3750) on fecal levels will also be measured.

Enrollment

36 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

18-65 years of age
Ability to provide written informed consent
Confirmed diagnosed with UC by colonoscopy and histology and suffering from mild to moderate UC as defined by MMDAI with score of 3-9
On a stable dose of aminosalicylate (i.e. no change in medication within 4 weeks of study enrollment) and not planning to initiate new medication other than the study drug
For women of childbearing potential or men with a partner of childbearing potential, agree to use birth control methods (including hormonal contraceptives, intrauterine device (IUD) or hormone releasing system (IUS), vasectomy) and men will refrain from donating sperm during the study and at least 30 days after dosing (per FDA guidelines)
For the expansion cohort, a flexible sigmoidoscopy is required, unless an endoscopy was completed within 3 months from enrollment is available
Refrain from receiving any type of vaccinations during the study period (to include but not limited to influenza, COVID, shingles, tetanus, hepatitis, pneumonia, HPV, DPT, MMR, and polio)

Exclusion criteria

Pregnancy, planned pregnancy, breastfeeding women
Evidence of severe UC disease (MMDAI score greater than or equal to 10)
Evidence of any active or recent infection including chronic infectious disease such as Hepatitis B, C, or HIV
Evidence of any active or recent chronic chest infection with bronchiectasis or sinusitis, or covid-19 infection in the past 3 months
Treatment with immunosuppressants or anti-cancer drugs, e.g., anti-TNF-α agents, anti-integrin agents, azathioprine or 6-MP, 6-thioguanine, methotrexate, ozanimod, tofacitinid, upadacitinib, tacrolimus, cyclophosphamide, or cyclosporine or any other therapy that is not an aminosalicylate within the last 3 months
Received an investigational drug within 3 months (or 5 half-lives, whichever is longer) before study entry
Use of steroidal drugs to treat UC (e.g., prednisone >20 mg/day)
Use of probiotics within the last one (1) week and during the trial.
Treatment with systemic broad-spectrum antibiotics in the past 2 months
Major active systemic autoimmune disease other than UC
History of anaphylaxis or allergies to probiotics
History of alcohol or drug abuse within the past 2 years
History of stroke, or any cerebrovascular disease requiring medication/treatment
History of cancer, apart from successfully treated basal cell carcinoma or in situ carcinoma of the cervix >1 year prior to enrollment
Significant laboratory abnormalities, including liver transaminases (AST or ALT) > 1.5X the upper limit of normal.
Second degree or higher heart block or clinically significant arrythmia
Any other clinically significant renal, hepatic, hematological or other disease or laboratory abnormality which, in the opinion of the investigator, would interfere with the conduct, the interpretation of the safety signals or results of the trial, or would place the subject at unacceptable risk
Any condition or circumstance that, in the opinion of the Principal Investigator, would compromise the safety of the subject or the quality of study data