RAAS and Arterial Stiffness in SCI

James J. Peters Veterans Affairs Medical Center

Status: Completed

Conditions: Hypotension; Renin Angiotensin Aldosterone System; Spinal Cord Injury; Orthostatic Hypotension; Arterial Stiffness

Treatments: Other: Spinal Cord Injury

Study type: Observational

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT04510974

WEC-18-025

Details and patient eligibility

About

The study is examining differences in central arterial stiffness, orthostatic changes in blood pressure, norepinephrine, and plasma renin in individuals with spinal cord injury compared with age-matched uninjured controls.

Full description

The study is examining differences in central arterial stiffness, orthostatic changes in blood pressure, norepinephrine, and plasma renin in individuals with spinal cord injury compared with age-matched uninjured controls. Arterial stiffness and blood pressure will be collected in the laying down position. A blood sample of norepinephrine and plasma renin will also be collected. The participant will tilt to 30, 45 and 60 degrees for 10 minutes at each angel. Blood pressure and heart rate will be monitored at each angle. Another blood sample of renin and norepinephrine will be collected at the end of 10 minutes at 60 degrees.

Enrollment: 33 patients

Sex: All

Ages: 21 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• SCI participants:
• injured between C1-T1 and T6-T12
• wheelchair dependent
• AIS classification A, B or C
• Injured occurred more than 1 year ago

Exclusion criteria

• currently have an illness or infection
• current smoker of at least 1 year
• controlled or uncontrolled hypertension or diabetes mellitus
• Neurological condition other than SCI (Alzheimer's disease, dementia, stroke, multiple sclerosis, Parkinson's disease)
• cardiovascular disease (coronary heart disease, congestive heart failure, peripheral artery disease)

Trial design

33 participants in 3 patient groups

Cervical SCI

Description:

Ages between 21-70 years old Injured between C1-T1 Wheelchair dependent AIS classification of A, B or C Injury occurred more than 1 year ago

Treatment:

Other: Spinal Cord Injury

Thoracic SCI

Description:

Ages between 21-70 Injured between T6-T12 Wheelchair dependent AIS classification of A, B or C Injury occurred more than 1 year ago

Treatment:

Other: Spinal Cord Injury

Able-bodied Control

Description:

Ages between 21-70