Racial Differences in Phosphorus Metabolism
Status
Completed
Conditions
Control
Treatments
Drug: 1-34 parathyroid infusion
Study type
Interventional
Funder types
Other
NIH
Identifiers
Details and patient eligibility
About
The investigators aim to study potential racial differences in renal phosphorus handling by provocatively testing urinary phosphorus excretion using parathyroid hormone infusions in healthy white volunteers compared to healthy black volunteers.
Enrollment
26 patients
Sex
All
Ages
18+ years old
Volunteers
Accepts Healthy Volunteers
Inclusion criteria
- 18 years of age or older
- Body mass index (BMI) within 20% ideal for their age and gender
Exclusion criteria
- Abnormal urinalysis
- Pregnancy or breast-feeding
- Medical conditions impacting phosphorus metabolism-primary hyperparathyroidism; diabetes mellitus; gastrointestinal malabsorption disorders; hyper- or hypothyroidism
- Medications known to affect phosphorus metabolism- current use of phosphorus supplements, phosphorus binders, calcitriol or calcitriol analogues, regular antacid or laxative use, calcitonin, etidronate, anticonvulsants
- Hyper- or hypophosphatemia (≥ 4.6 mg/dl or ≤ 2.5 mg/dl respectively), hyper- or hypocalcemia (≥ 10.6 or ≤ 8.5 mg/dl respectively), or severe anemia (Hgb < 8 g/dl for women and < 9 g/dl for men)
Trial design
Primary purpose
Diagnostic
Allocation
N/A
Interventional model
Single Group Assignment
Masking
None (Open label)
26 participants in 1 patient group
PTH infusion
Experimental group
Description:
(1-34) PTH infusion at a rate of 0.055 ug/kg/hour for six hours
Treatment:
Drug: 1-34 parathyroid infusion
Trial contacts and locations
1
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Data sourced from clinicaltrials.gov
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