Radiation Biodosimetry in Children Undergoing Total Body Irradiation

Medical College of Wisconsin

Status: Completed

Conditions: Hematopoietic Stem Cell Transplant; Total-body Irradiation

Study type: Observational

Funder types: Other

Identifiers

NCT01337648

RadBio-10/191

Details and patient eligibility

About

The purpose of this study is to develop fecal tests that will determine the extent of radiation exposure in patients undergoing radiation treatment for cancer. This project will determine whether fecal biomarkers can be used to diagnose exposure to radiation.

Full description

Patients undergoing TBI as part of a hematopoietic stem cell transplant (HSCT) will have feces collected for use in the validation and refinement of new methods for rapid radiation biodosimetry. The stool samples will be collected before, and at defined times after TBI. Stool sampling will occur in the same manner that it does during routine patient care during HSCT.

Enrollment: 2 patients

Sex: All

Ages: 2 to 21 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• All races are eligible
• 2 years to 21 years old
• Must be undergoing hematopoietic stem cell transplantation (either autologous or allogeneic) in conjunction with a conditioning regimen that includes total-body irradiation (TBI) (single or multiple fraction).

Trial design

2 participants in 1 patient group

TBI prior to stem cell transplantation